We can ship REGEN + worldwide.

Unique component intended for:

– regeneration of injured horse tendons as REGEN-TENDON
– regeneration of damaged articular cartilage as REGEN-CARTILAGE
– regeneration of damaged eye corneal cells as REGEN-CORNEA

INDICATIONS
It is mainly used in horses in a case of tendon injury, joint degeneration and eye corneal damage.
But it can also be used in small animals (dogs, cats).

INFORMATION LEAFLET – APPLICATION OF REGEN+
INFORMATION LEAFLET – REHABILITATION PROGRAM + TENDON PROPHYLAXIS

CLINICAL DATA of REGEN-TENDON

1. REGEN-TENDON is considered as safe with no side reaction observed after application. It has been tested on 10 horses as a local intra tendon, peri-tendon, intra-articular injections.

2. REGEN-TENDON has been used in more than 30 clinical cases of superficial digital flexor tendon (SDFT) injuries. The best results have been achieved when 3 – 5 days after SDFT injury REGEN-TENDON combined with NSAID and cold therapy has been used. Rehabilitation program has been applied afterwards.

3. Applications of REGEN-TENDON have also improved healing of deep digital flex or tendon (DDFT) injuries, chronic tendonitis and suspensory ligament desmitis in sport and endurance horses.

Rehabilitation program should be applied including walking and swimming program for the following 3 months (12 weeks), slowly introducing horse into work with close USG monitoring.

4. TENDON PROPHYLAXIS – prevention of injury
Peri-tendon injection of REGEN-TENDON should be applied one day after sport event (such as race, endurance) in order to prevent incoming tendon injury / rupture. Even if there is no clinical signs of injury, REGEN-TENDON helps recovering from all micro-injuries observed with UTC.

Examples of REGEN-TENDON intra-tendon injections into SDFTs (3  x sport horses, Thoroughbreds) by USG.

0 d / 60 days

0 d / 60 days

0 d / ~ 30 days

Examples of REGEN-TENDON peri-tendon injections into SDFTs (3  x sport horses, Thoroughbreds) by UTC*.

Case 1
Thoroughbred/SDFT/LF

Before injection

After injection – 3 MONTHS

peri-tendon application along the tendon (left/right side)

horse under rehabilitation

Case 2
Thoroughbred/SDFT/RF

Before injection

After injection – 3 MONTHS

peri-tendon application along the tendon (left/right side)

horse under rehabilitation

Case 3
Thoroughbred/SDFT/RF

Before injection

After injection – 2 MONTHS

peri-tendon application along the tendon (left/right side)

horse under rehabilitation

* LEGEND: Ultrasound tissue characterisation (UTC)

4 types of ultrasound echoes – color coded – are very specific to tendon tissue, representing the integrity of tendon matrix.

  • Green: (type I echo) is normal, well-aligned and organized tendon bundles. At least 85–90% of this type of echo should be located in a healthy tendon.
  • Blue: (type II echo) there are areas of wavy or swollen tendon bundles. They represent tendon remodeling and adaptation or lower-order repair.
  • Red: (type III echo) it denotes fibrous tissue (the basic building block of a tendon). It may indicate a partial tear of the tendon, which reflects breakdown of the normal structure. It may also indicate initial healing of the tendon.
  • Black: (type IV echo) it denontes areas of cells or fluid. These are spinal changes of the tendon where there is no normal tendon tissue.

Literature: https://www.utcimaging.com/wp-content/uploads/2024/02/Sarah-Plevin_Ultrasound-Tissue-Characterization_The-Practitioner_3-2020.pdf

REGEN-TENDON can be used in horse tendons injury up to 30% as the standard treatment.
There were also extreme cases of tendon injuries reaches up to 70% with successful results.

After application of REGEN-TENDON it takes 3 – 6 months to heal depending on the severity of the injury, whereas standard healing process takes 7 – 9 months. Always remember to implement a rehabilitation program.

REGENERATION OF ARTICULAR CARTILAGE – REGEN-CARTILAGE
Look here: INFORMATION LEAFLET – APPLICATION OF REGEN+

After intra-articular injection REGEN+ in combination with hyaluronic acid (1 – 2%) acquires the following features:

  • anti-inflammatory, 
  • moisturizing,
  • supplementing synovial fluid, 
  • accelerates regeneration of damaged articular cartilage
    (Basic fibroblast growth factor promotes cartilage repair in vivo, 1988).

REGENERATION OF CORNEA CELL – REGEN-CORNEA
Look here: INFORMATION LEAFLET – APPLICATION OF REGEN+

EXAMPLES OF SCIENTIFIC LITERATURE

  1. Biologics for tendon repair. Advanced Drug Delivery Reviews 84 (2015) 222–239.
  2. Clinical Implications of Growth Factors in Flexor Tendon Wound Healing. J Hand Surg 2004;29A:551–563.
  3. Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons. Nature – Scientific Reports, 6:20643, 2016.
  4. The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elbow Surg (2009) 18, 391-398.
  5. Gene Therapy Using Plasmid DNA Encoding Vascular Endothelial Growth Factor 164 and Fibroblast Growth Factor 2 Genes for the Treatment of Horse Tendinitis and Desmitis: Case Reports. Gene Therapy Tendinitis and Desmitis, October 2017, Volume 4, Article 168.
  6. The Roles of Growth Factors in Tendon and Ligament Healing. Sports Med 2003; 33 (5).
  7. Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges. Stem Cell Research & Therapy (2019) 10:181. 
  8. Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo. BBRC, Vol.156, Issue 2, 1988.